Its related demethylase, JMJD2C (i.e., KDM4C), is found to be upregulated by HIF-1α and it can serve as a co-activator for HIF-1α which epigenetically modulates metabolic reprogramming and metastasis in breast cancer cells by decreasing H3K9me3 as well [30]. Here, HIF1A is linked to breast carcinoma.