MAT2A and hepatocellular carcinoma: Recently, Liu et al. have found that hypoxia can induce global DNA demethylation by transcriptionally upregulating methionine adenosyltransferase II, alpha (MAT2A) in human hepatoma cells, maintaining the S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) ratio at a low level [40].