NME1 and breast carcinoma: Previous reports suggested that EBNA3C has an important role in reversing Nm23-H1-mediated inhibition of cellular migration after co-expression with Nm23-H1 in a breast carcinoma cell line and an EBV-negative BL cell line, demonstrating that EBNA3C can potentially promote metastasis in EBV-positive tumors by modulating Nm23-H1 activities (Figure 2) [135].