Natural products including green tea extract, coffee and several extracts of medical plants have been hypothesized to prevent NAFLD or its progression via several mechanisms, such as sensitizing insulin effects, activating adiponectin expression, and down-regulating pro-inflammatory cytokines, by antioxidant effects or by anti-dyslipidemic properties [23,24,25]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.