In the United Kingdom Prospective Diabetes Study (UKPDS), the intensive blood-glucose control in newly diagnosed T2DM patients, by either sulphonylureas or insulin, resulted in a long-term (10 years after the cessation of randomized interventions) risk reduction for myocardial infarction (15%), when compared with the conventional treatment group (diet) [12]. This evidence concerns the gene INS and type 2 diabetes mellitus.