ECG and chest radiograph did not show any alteration, whereas hematological analyses revealed leukocytosis in all patients (15 to 34 × 103 cells/μL) with high levels of neutrophils (patients 3 and 4: 31 and 15 × 103 cells/μL), creatine phospho-kinase (CPK; patient 1: 215 IU/L) and C-reactive protein (CRP; patients 2, 3, and 4: 28–228 mg/L). This evidence concerns the gene PIK3C2A and Increased total leukocyte count.