EVs in the size range and appearance of LO have been recently described with different names including: (1) giant vesicles, identified in ERα-positive breast cancer cells and tumor tissues [49]; (2) migrasomes, large round structures containing numerous vesicles (pomegranate-like structures), which depart from retraction fibers of migratory benign cells [50]; and (3) tumor-derived MV originating from amoeboid-like tumor cells, in which VAMP3 seems to regulate the delivery of MV cargo to regions of high plasma membrane blebbing. The gene discussed is VAMP3; the disease is neoplasm.