Furthermore, when DCs were loaded with a B16F10 melanoma cell lysate to produce dexosomes containing tumor antigens, the resulting vaccine strongly induced activation of melanoma-specific CD8+ T-cells and recruitment of cytotoxic CD8+ T-cells, NK and NK-T-cells to subcutaneously grafted B16-F10 melanoma tumors in C57BL/6 mice. Here, CD8A is linked to melanoma.