Undoubtedly, an expanded and inflamed (dysfunctional) visceral adipose tissue plays a key role in the development of insulin resistance, chronic inflammation and NAFLD, possibly through the secretion of multiple factors, such as increased release of non-esterified fatty acids, increased production of various hormones and pro-inflammatory adipocytokines (including also TNF-α, IL-6, leptin, visfatin, and resistin), and decreased production of adiponectin [9,31,32,33,34]. This evidence concerns the gene IL6 and Insulin resistance.