Prevalence of NAFLD was remarkably higher in psoriatic patients than in matched controls (47% vs. 28%; p < 0.001). Patients with psoriasis and NAFLD were more likely to have metabolic syndrome and had higher serum C-reactive protein concentrations and greater severity of psoriasis according to PASI score than those with psoriasis alone. At multivariate linear regression analysis, NAFLD was associated with higher PASI score (standardized β coefficient 0.19, p = 0.03), independent of age, sex, BMI, psoriasis duration and alcohol consumption. This evidence concerns the gene CRP and psoriasis.