Prevalence of NAFLD was higher in subjects with psoriasis than in those without psoriasis (44.3% vs. 34%, p < 0.05). Moreover, prevalence of advanced liver fibrosis was 8.1% in psoriatic patients compared with 3.6% in the control group (p < 0.05). Multivariate logistic regression analysis revealed that the risk of advanced liver fibrosis remained higher in psoriatic patients after adjustment for age, sex, alcohol consumption, serum ALT levels, presence of metabolic syndrome and hepatic steatosis (OR 2.57, 95% CI 1.0–6.6) The gene discussed is GPT; the disease is psoriasis.