Overexpression of CIZ1 increases the transcription of Wnt signaling target genes c-Myc, Snail, and Cyclin D1, and promotes the proliferation and migration of gallbladder cancer cells, while knockdown of CIZ1 remarkably inhibits gallbladder tumor formation in a xenograft mouse model [14]. This evidence concerns the gene CIZ1 and gallbladder cancer.