CIZ1 and early-onset autosomal dominant Alzheimer disease: In a subtractive cloning screen for novel candidate genes of Alzheimer’s disease, an alternative splicing variant of CIZ1 mRNA in exon 8 is moderately overexpressed in the hippocampus of patients with Alzheimer’s disease, and the level of full-length CIZ1 mRNA is not altered between the two groups [7].