mRNA expression levels of selected genes of complement system (C1QL1, C1QTNF7, C3AR1), colony stimulation factors (CSF1R, CSF3R), Toll-like receptors (TLR4, TLR7), IL8, pro-inflammatory cytokines (IL6, IL6ST, IL1B), TNF-α family (TNFRS1A, TNF-α), IL-10 family (IL10, IL10RA, IL10RB), and TGF-β family (TGFB1, TGFB2) were analysed in 20 middle-aged individuals with no neuropathological lesions, 58 age-matched controls, 105 cases of sporadic AD, 56 cases of sporadic PD, 30 cases of sCJD (15 MM1 and 15 VV2), and 18 tauopathies. This evidence concerns the gene TNF and tauopathy.