ABCA7, CLU, and CRI are implicated in the complement response; TREM2 regulates cytokine production; HLA-DRB5, like other molecules related to the HLA Class II, is involved in the presentation of immune-peptides; EPHA1 and INPP5D participate in inflammatory responses although their exact mechanism is not known; finally, the role of PICALM, PLD3, and SORL1 in the control of inflammation is poorly understood in AD, but PICALM seems to interact with APOE genotypes [41,64]. Here, APOE is linked to Alzheimer disease.