This is followed by a description of unpublished observations in the frontal cortex in tauopathies including Pick’s disease, progressive supranuclear palsy and frontotemporal lobar degeneration linked to the P301L mutation in MAPT. This last set of data was considered appropriate to includea here as it was obtained using the same methods and procedures as in studies noted in previous paragraphs, and it further documents disease specificities in the inflammatory response among neurodegenerative diseases with abnormal protein aggregates. This evidence concerns the gene MAPT and neurodegenerative disease.