Decreased expression of C3AR1, TLR7, and TNFα, and increased expression of C1QTNF7 and IL10RA mRNAs, was observed in the putamen; down-regulation of CSF3R and TLR4, and up-regulation of IL10RA, were seen in the frontal cortex (area 8); and up-regulation of C3AR1, CSF3R, IL10RA, and TGB2 mRNAs was observed in the angular cortex (area 39) in the same series of PD cases. This evidence concerns the gene C3AR1 and Parkinson disease.