Summary of gene regulation in the frontal cortex are 8 in Alzheimer’s disease (AD) at stages A.; B and C.; Parkinson’s disease (PD); Creutzfeldt-Jakob disease (CJD) subtypes MM1 and VV2.; Pick’s disease (PiD).; progressive supranuclear palsy (PSP).; and frontotemporal lobar degeneration linked to mutation P301L in MAPT (FTLD-tau). The gene discussed is MAPT; the disease is Alzheimer disease.