Post-mortem samples of the frontal cortex area 8 of five cases with Pick’s disease, eight cases with progressive supranuclear palsy typical form, and five cases with frontotemporal lobar degeneration linked to mutations in MAPT (FTLD-tau P301L) were analyzed in parallel with frontal cortex area 8 of age-matched controls. This evidence concerns the gene MAPT and Classical progressive supranuclear palsy.