ACHE and Alzheimer disease: Several potent dual binding site AChE inhibitors act simultaneously on two aspects of AD pathology, e.g., amyloid modulation and AChE inhibition [7], and they bear different cores, such as phthalimide [1], substituted indanone or indane [1,8,9,10], indole [11], alkoxybenzene [12] or N-benzyl-piperidine or -piperazine rings [13,14] connected to the acridine scaffold by diverse nitrogen-containing bridges, mimicking donepezil (1) and tacrine (2) moieties.