INS and diabetes mellitus: This difference likely reflects the fact that FACTOR 64 enrolled a population of diabetics with higher cardiovascular risk—when compared to our study, the FACTOR 64 population had a greater proportion of men, an older cohort (62 vs. 55 years in our study), a longer duration of diabetes (13.9 vs. 5.2 years), and a higher rate of insulin use (43 vs. 22 %) [41].