Further, Demelash et al. [21] demonstrated that CDK5 played a vital role in the regulation of lung cancer cell migration and invasion through Wound closure and Boyden chamber assay and certified that achaete-scute homologue-1 (ASH1), a basic transcription factor which was expressed in lung cancer cells with neuroendocrine features [29], could stimulate migration of lung cancer cells through CDK5/p35 pathway. This evidence concerns the gene CDK5 and lung carcinoma.