CYBB and chronic granulomatous disease: Accordingly, IFN-γ gene knockout renders mice susceptible to intracellular infections.17 In addition, patients suffering from CGD, in which mutations in gp91phox may be inherited, gain effective prophylaxis from opportunistic infection by treatment with subcutaneous IFN-γ.7 We, therefore, evaluated whether exogenous IFN-γ administration could restore defective in vitro MOB in patients with SAH.