IL1B and ischemic stroke: Although, it is well documented that IL-1Ra attenuates the pro-inflammatory activities of IL-1(α/β) [6, 20, 39, 60, 61], key information about the cellular production of IL-1Ra and IL-1(α/β), and its orchestration in the tissue at risk in ischemic stroke is still lacking, but pivotal to the development of new therapeutic strategies.