CCL5 and bacterial meningitis: In experimental bacterial meningitis, CCL2 and CCL5 were found to be significantly elevated in cerebrospinal fluid (CSF), together with leukocyte infiltration [52], and antibodies neutralizing CCL2/CCL3 have been shown to mitigate neutrophil and macrophage recruitment into the brain [53], suggesting potential therapeutic efficacy for the chemokine-regulating andrographolide in bacterial meningitis.