Interestingly, Wnt1-cre;Gsαf/f mutants show round face (Fig 1K), shortened snout (Fig 1G, 1I and 1K), hypertelorism (Fig 1G) and craniosynostosis (Fig 2A), these phenotypes are highly similar to the clinical phenotypes observed in GNAS mutations diseases. Here, GNAS is linked to craniosynostosis.