The aim of this study was to perform a retrospective assessment, in tumor samples after surgery and before chemotherapy, of the relation between the expression of oxaliplatin transporters (OCT1, OCT2, OCT3, CTR1 and ATP7B) and the response to adjuvant FOLFOX-4 chemotherapy, in responder and non-responder patients. The gene discussed is SLC22A3; the disease is neoplasm.