NCAN and bipolar disorder: The NCAN gene is located just 10095 bp at 5′ from RFXANK, and is one of the few genetic variants that has been genome-wide replicated as a risk factor in both bipolar disorder and schizophrenia.32, 33 In addition, a recent study focusing on the cortical thickness and folding in schizophrenia patients found evidence for association of the NCAN genetic variant in the occipital and prefrontal cortex.34 The SNP rs874628 (MPV17L2 gene), located in this locus, was implicated in multiple sclerosis, an inflammatory disease with disruptions in the nervous system.35