49 A dysregulation of CLEC4M may have significant consequences in the pathogenesis of infectious diseases.50 Although ME/CFS has been associated with numerous viral infections or reactivations, including Epstein Barr virus,51 Enterovirus9 and Parvovirus B19,52 a causative infectious agent has never been identified. Here, CLEC4M is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.