For example, multiple SNPs within the RNASEL gene have been associated with prostate cancer,61 and several SNPs in the CDKN2B and ANRIL genes have been associated with cardiovascular disease.62 In addition, the distinct haplotypic patterns of some of the cases in these regions may suggest that these genes are involved in a mechanism that separates the ME/CFS cases into distinct subgroups. This evidence concerns the gene CDKN2B-AS1 and cardiovascular disorder.