Similarly, we identified 1 TSC1 splicing variant (renal cell carcinoma), 1 TSC1 nonsense mutation (anaplastic thyroid cancer), 1 TSC1 missense mutation (sarcoma) and 1 TSC2 missense mutation (angiosarcoma). The gene discussed is TSC2; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.