Mutational activation of the epidermal growth factor receptor (EGFR) pathway is the major pathogenic event in non tobacco-induced adenocarcinoma (ADC), whereas the pathway driven by v-Ki-ras2/Kirsten rat sarcoma viral oncogene homolog (KRAS) is involved in tobacco-mediated lung carcinogenesis [3–6]. This evidence concerns the gene KRAS and AIDS dementia complex.