CD8A and Sepsis: IL-15 SA treatment did not impact blood absolute lymphocyte counts after burn injury or burn plus infection, but increased CD4+T, CD8+T, NK, NKT and B lymphocytes in both spleen and liver tissue Sepsis is known to cause significant apoptosis-mediated death of monocytes, T, B, dendritic, and NK cells, which is postulated to cause immunosuppression and increased susceptibility to infection [54,55].of burned mice.