TNF and colorectal carcinoma: In this model, CRC patients who had higher plasma levels (≥ROC value) of IL-1 (P = 0.01), CXCL8 (P<0.001), IL-10 (P = 0.01), PTX3 (P = 0.002), IL-6 (P = 0.06), and VEGF (P<0.001) associated with worse prognosis (Table 3), while higher levels of CCL2 (P = 0.31) and TNF-a (P = 0.89) (Table 3) did not.