We found that patients who did not relapsed (n = 54) had significantly lower plasma concentrations of IL-1 (P = 0.008), IL-6 (P = 0.01), IL-10 (P = 0.04), CXCL8 (P≤0.001), VEGF (P≤0.001) and TNFalpha (P = 0.02) compared to those who experienced recurrence of CRC disease (n = 9) (Fig 1). This evidence concerns the gene IL10 and colorectal carcinoma.