The use of VEGF inhibitors, such as avastin, gives some results, especially in colorectal, breast, lung cancer and glioblastoma where it is able to induce vascular normalization and reducing hypoxia (leading to improved efficacy of conventional therapies) [131] nevertheless anti-angiogenic drugs have been shown not to be always effective in the treatment of cancer, particularly for the highly aggressive ones [12]. The gene discussed is VEGFA; the disease is cancer.