Therefore, in the current study we will continue to experimentally validate the regulation of HO-1 by CD147 and viral latent protein, investigate the role of HO-1 in KSHV-infected endothelial cell pathogenesis and tumorigenesis, and determine the anti-cancer effects of a HO-1 selective inhibitor by using an established KS-like xenograft model. Here, BSG is linked to Kaposi's sarcoma.