While we cannot formally rule out the possibility that mesenchymal-appearing tumor cells in this model reflect the outgrowth of a small number of Lgr5+ mesenchymal cells or expansion of a bone marrow-derived cell population, the contiguous appearance of ECad+ and ECad− tumor cells, and the occasional colocalization of epithelial and mesenchymal markers in tumor cells, argue against this possibility. Here, LGR5 is linked to neoplasm.