MCL1 and neuroblastoma: The induction of apoptosis in MYCN-amplified neuroblastoma cells was mitigated by BIM siRNA (Figures 5C and S6C), implicating that the disruption of BIM/MCL-1 complexes leads to loss of MCL-1-bound BIM and contributes to ABT-199/MLN8237-mediated apoptosis.