MYCN and neuroblastoma: Consistent with a role of amplified MYCN in BCL-2 family-mediated apoptosis following cellular stress, BCL-2 overexpression from serum deprivation and metabolic stress can counter MYCN-mediated apoptotic signaling in neuroblastoma and, therefore, cooperate in tumorigenicity (Jasty et al., 2001, Ushmorov et al., 2008).