These data altogether demonstrate that MLN8237 downregulation of MCL-1 contributes to the sensitivity of MYCN-amplified neuroblastoma cells to ABT-199/MLN8237 by disrupting BIM:MCL-1 complexes and that ABT-199/MLN8237 combination-induced apoptosis is, at least in part, mediated by BIM. The gene discussed is MYCN; the disease is neuroblastoma.