BCL2 and neuroblastoma: To explore the underlying etiology for this exquisite sensitivity of MYCN-amplified cell lines, we examined expression levels of BCL-2 family members that are known to modulate the sensitivity to ABT-263 by interrogating a database of 20 MYCN-amplified and 81 MYCN-WT neuroblastoma primary tumors (Wang et al., 2006).