However, clinical confusion from clinical criteria based upon AHA guidelines for diagnosing KD, including ESR [receiver operating characteristic (ROC) area under the curve (AUC): 0.689 for continuous ESR; 0.625 for elevated ESR≥40mm/hr], CRP (ROC AUC: 0.693 for continuous CRP; 0.619 for elevated CRP≥3mg/DL) and combination of elevated ESR or elevated CRP (ROC AUC: 0.568) as shown in S2 Fig, can lead to a missed or delayed diagnosis and timely treatment, resulting increased risk of coronary artery aneurysms. The gene discussed is CRP; the disease is coronary aneurysm.