MiR499 is an evolutionarily conserved muscle-specific miRNA that is encoded within the intron of myosin heavy chain 7B (Myh7B) and is highly enriched in cardiac ventricular myocytes.[8, 9] miR499 has been demonstrated to be involved in the pathogenesis of valvular heart disease, ischemic heart disease, and heart failure.[10–12]. The gene discussed is MYH7B; the disease is heart failure.