The network described in our study displays downregulation of miR-146a-5p in primary ccRCC of M1 patients to be associated with a significant upregulation of the target mRNAs BRCA1, MCM10, CDKN3, CXCL8, and UHRF1 (Fig 3). This evidence concerns the gene CXCL8 and nonpapillary renal cell carcinoma.