When grouped according to the various histological types of digestive cancer, the combined HRs of oesophageal cancer was (HR = 1.54, 95% CI: 1.27–1.81), indicating EZH2 was an indicator of poor prognosis in oesophageal cancer (P = 0.035 for heterogeneity test). This evidence concerns the gene EZH2 and carcinoma of esophagus.