Many new tumor-suppressor candidates have been identified, including the cell motility regulator testis-derived transcript (TES) as well as many polycomb repressor complex 2 (PRC2) target genes (54), and epithelial membrane protein 3 (EMP3), a myelin-related gene involved in cell proliferation and cell–cell interaction that is silenced by hypermethylation in glioblastoma (55). Here, EMP3 is linked to glioblastoma.