The best known example is the O6-MGMT promoter methylation and response to alkylating agents, but there is also the gene suppressor of cytokine signaling 1 (SOCS1), which in some glioblastomas enhanced resistance to ionizing radiation and decreased activation of MAPKs associated with the ERK pathway after transcriptional silencing by hypermethylation (58). The gene discussed is MGMT; the disease is glioblastoma.