Large-scale sequencing of protein-coding genes in glioblastoma revealed mutations in many genes involved in epigenetic regulation, including HDACs, HDAC2 and HDAC9, histone demethylases, JMD1A and JMD1B, histone methyltransferases, SET7, SETD7, MLL, MLL4, and methyl-CpG binding domain protein1 (MBD1) (6). This evidence concerns the gene HDAC9 and glioblastoma.