Nine factors were tested to identify predictive factors of anastomotic leakage: age at operation, serum albumin ≤35 g/L, serum CRP > 10 mg/L, preoperative nutritional therapy, penetrating behavior as the indication for resection, preoperative corticosteroids, intraoperative abscess, being active smoker, and preoperative azathioprine or Tripterygium wilfordii Hook. The gene discussed is ALB; the disease is abscess.