INPP5B and oculocerebrorenal syndrome: This turnover, which occurs at the base of the phagocytic cup (81), is directly dependent on the hydrolysis of PI(4,5)P2 (82), which is mediated by several effectors including phosphatases that hydrolyze PI(4,5)P2, such as phospholipase C, PI3 kinase, and 5′ phosphatases, such as Inpp5b or oculocerebrorenal syndrome of Lowe (OCRL) (81, 83–85).