MIF and Sepsis: The thyroid hormone thyroxine (T4) and its dextrorotatory isomer (dextrothyroxine; d-T4), but not triiodothyronine (T3), bind to the hydrophobic pocket within the MIF molecule and has been shown to be a potent inhibitor of the inflammatory activity of MIF in a dose-dependent manner, which was clearly demonstrated by administration of exogenous d-T4 to mice with severe sepsis (65).