In our study, we found significantly higher levels of IGFBP-1 in both T1D with and without complications as compared to controls; however, the differences were larger in T1D with complications (second quintile OR = 2–6; third quintile OR = 4–8; fourth quintile OR = 4–23; and fifth quintile OR = 5–19). Here, IGFBP1 is linked to type 1 diabetes mellitus.