IGFBP2 and type 1 diabetes mellitus: For T1D complications, the strongest association is observed with IGFBP-2 (p-trend = 10−27–10−35) followed by IGFBP-1 (p-trend = 10−16–10−20), IGFBP-3 (p-trend = 10−05–10−15), and IGFBP-6 (p-trend = 10−04–10−13).