In our study, we found a significant association between the decreased levels of IGFBP-3 and T1D complications (second quintile OR = 0.67–0.93; third quintile OR = 0.29–0.8; fourth quintile OR = 0.15–0.53; fifth quintile OR = 0.13–0.36). Here, IGFBP3 is linked to type 1 diabetes mellitus.