Whereas, in T1D with complications IGFBP-1, -2, -3, and -6 showed highly significant associations (IGFBP-1: OR = 2.4, 4.1, 8.2; IGFBP-2: OR = 2.4, 4.8, 8.4; IGFBP-3: OR = 0.48, 0.52, 0.67; IGFBP-6: OR = 1.8, 3.6, 10, for 1Comp, 2Comp and 3Comp groups, respectively) (Table 3). The gene discussed is IGFBP2; the disease is type 1 diabetes mellitus.