Although previous results from our group in 2K1C mice demonstrated that PDE5 chronic inhibition was able to reduce clipped kidney atrophy (Dias et al., 2014a,b), this difference is probably due to the fact that the treatment started 14 days after renal artery clipping, when renovascular hypertension is still developing and is not yet fully established (Navar et al., 1998). The gene discussed is PDE5A; the disease is renovascular hypertension.