Nowadays, it is well-accepted that the mechanisms underlying impaired baroreflex control of blood pressure in hypertension involve, at least in part, Ang II-mediated increase in oxidative stress along the axis formed by subfornical organ, paraventricular nucleus of the hypothalamus and rostral ventrolateral medulla (SFO-PVN-RVLM; Braga et al., 2011; de Queiroz et al., 2013). The gene discussed is AGT; the disease is hypertensive disorder.