Pim-1 seems like a potential target for drug discovery, in fact in pediatric preclinical models, Pim1 inhibitor SGI-1776 has been shown to induce complete response to subcutaneous MV4:11 leukemia (Batra et al., 2012) as well as inhibit proliferation in other malignancies such as CLL, B cell lymphoma, multiple myeloma, etc. (Cervantes-Gomez et al., 2013, 2015; Yang et al., 2013). Here, PIM1 is linked to B-cell non-Hodgkin lymphoma.