SLC12A5 and epilepsy: Chloride dysregulation caused by reduction of KCC2 expression or function is an important cause of disinhibition associated with several neurological and psychiatric disorders including epilepsy, chronic pain, motor spasticity, and schizophrenia (Coull et al., 2003; Jin et al., 2005; Price et al., 2005; Huberfeld et al., 2007; Hewitt et al., 2009; Boulenguez et al., 2010; Kaila and Miles, 2010; Arion and Lewis, 2011; Hyde et al., 2011; Ben-Ari et al., 2012).