Differential expression of various KCC2 transcripts in schizophrenia and affective disorders (Tao et al., 2012) and an “immature” ratio of NKCC1 to KCC2 in schizophrenia (Hyde et al., 2011; Kalkman, 2011) are both suggestive of clinically meaningful link between those diseases and Cl− dysregulation. Here, SLC12A2 is linked to schizophrenia.