Indeed, collapse of inhibition during repetitive inhibitory input is accelerated in pathological conditions such as epilepsy, stress disorders, and chronic pain (Jin et al., 2005; Hewitt et al., 2009; Ferrini et al., 2013) but the precise dependence on KCC2 level, especially with respect to settling time, has not been rigorously explored. This evidence concerns the gene SLC12A5 and epilepsy.