MAPT and Alzheimer disease: These factors are turned over by the UPS, and are perturbed in AD by either reduced expression, mis-localization, or an interaction with Tau (Carlucci et al., 2008; Trausch-Azar et al., 2010; Merrill et al., 2011; Manczak and Reddy, 2012; Sheng and Cai, 2012; Sheng et al., 2012).