Because Uch-L1 has been found play a role in synaptic function and BACE1 degradation (see below), it will be interesting to know whether UBB+1 has the opposite effect on synaptic plasticity in the AD brain, what signaling pathways are involved, and if UBB+1 also linked BACE1 degradation. The gene discussed is BACE1; the disease is Alzheimer disease.