OXTR and major depressive disorder: Another study found that youth possessing at least one A allele of the OXTR rs53576 SNP, whose mothers had had a history of depression (as measured at age 15, using the SCID-I scale), exhibited the highest levels of depressive symptoms at age 15 (as measured by the Beck Depression Inventory II; BDI-II), showing that SNP rs53576 acts as a moderator variable in the transmission of maternal depression from mothers to their children (Thompson et al., 2014).