Recent findings by Reiner et al. (2015), in a sample of 43 clinically depressed and 42 healthy female subjects, suggest epigenetic effects of the OXTR rs53576 genotype on the patterns of methylation in exon 1 and 2 of OXTR. This OXTR SNP moderated, for instance, the association between depression and OXTR exon 1 methylation level. Here, OXTR is linked to major depressive disorder.