Nyffeler et al. (2014) found, in a Caucasian population, that a significant part of the risk for high functioning autism is explained by the combination of four polymorphisms: HTTLPR (a polymorphic repeat inside the gene coding for the serotonin transporter), SNP rs6311 in HTR2A (which encodes the serotonin receptor 5-HT2A), and the rs2254298 and rs53576 SNPs in the OXTR. These data provide evidence supporting a polygenic inheritance of ASD, involving both the OXT and the 5-HT pathways (Nyffeler et al., 2014). The gene discussed is OXT; the disease is autism.