CXCR1 and hepatocellular carcinoma: Indeed, CXCL5, another CXCR2 ligand, has been shown to be associated with a high neutrophil load and poor outcome in hepatocellular carcinoma.48 CXCR1 and CXCR2 also promote neoangiogenesis in tumour tissue.30, 31 Hence, blockade of CXCR1/2 signalling may not only beneficially affect acute inflammation and the development of steatosis, but could potentially also decrease the risk of hepatocellular carcinoma.