Genetic deletion of CXCR1 or its blockade by repertaxin resulted in a significant decrease of BrdU incorporation into proliferating hepatocytes.47 In this model of ischaemia/reperfusion injury, which indeed causes one single assault to the liver tissue, immigrating neutrophils are a good prognostic factor and facilitate repair and regeneration.47 In ASH, in contrast, with alcohol present as a constant noxa, repair and regeneration might result in hyperproliferation and consequent development of neoplasia. The gene discussed is CXCR1; the disease is neoplasm.