CASP1 and fatty liver disease: IL-1β secretion due to caspase-1 activation in Kupffer cells has previously been shown to induce hepatic steatosis, and blockade with recombinant IL-1 receptor antagonist (IL-1Ra, Anakinra) in experimental steatohepatitis attenuated liver inflammation.37 In our model of experimental ASH, we show that blocking CXCR2 receptors downregulates the expression of pro-caspase 1.