Indeed, CXCL5, another CXCR2 ligand, has been shown to be associated with a high neutrophil load and poor outcome in hepatocellular carcinoma.48 CXCR1 and CXCR2 also promote neoangiogenesis in tumour tissue.30, 31 Hence, blockade of CXCR1/2 signalling may not only beneficially affect acute inflammation and the development of steatosis, but could potentially also decrease the risk of hepatocellular carcinoma. This evidence concerns the gene CXCR2 and steatosis.