Moreover, human patients carrying mutations (single homozygotes or compound heterozygotes) in CLC or CLF-1 (8, 12, 13) develop a series of similar manifestations known as Sohar-Crisponi or cold-induced sweating syndrome (CISS) (14, –, 16), which includes feeding difficulties and risk of early death. The gene discussed is CLC; the disease is cold-induced sweating syndrome.