CRLF1 and cold-induced sweating syndrome: Thus, apart from an insignificant (and seemingly harmless) decrease in motor neurons in old age, lack of CNTF appears to be innocuous (43), while compound mutations causing insufficient expression of CLC and/or CLF-1 result in a series of defects manifested in the form of human CISS/Sohar-Crisponi syndrome (8, 12, –, 16, 44).