HK2 and cancer: Further analysis of cancer cells treated with mitochondrial stressors and/or tamoxifen demonstrated that IL6 treatment reduced cell death (Supplementary Fig. 7a) and led to an increased expression of Notch3 and enzymes of aerobic glycolysis such as HK-2, PMK-2 and PDH-A (Fig. 5a, full blots Supplementary Fig. 9).