IL6 from the conditioned media of tamoxifen-treated cancer cells (CM-IL6+Tam) mediated the self-renewal capacity of TamR-FACS-isolated CD133hi cells, demonstrating the sufficiency of this cytokine in promoting exit from metabolic dormancy, while the same conditioned media promoted the growth arrest of CD133lo cells (Fig. 4d). This evidence concerns the gene IL6 and cancer.