In addition, 31 of 50 (66.03%; P < 0.02), and 19 of 27 (70.3%; P < 0.003) of liver tumors displaying induction of p-AKT and c-Met, respectively, belonged to the HCC subset with poorer outcome, linking the overexpression of these proteins to a dismal prognosis of HCC patients. This evidence concerns the gene AKT1 and hepatocellular carcinoma.