BRCA2 and neoplasm: However, tumours in BRCA1 mutation carriers were more likely to present with more advanced stage (42.9 % vs. 23.5 %, P for trend = 0.11) and were more frequently ER− (9.7 % vs. 3.3 %, P = 0.17) and PR− (21.4 % vs. 13.2 %, P = 0.27) than tumours in BRCA2 mutation carriers (Additional file 4).