BRCA2 and neoplasm: Among tumours with data on stage and grade, the majority of BRCA2 mutation carriers presented with stage 2 disease (47 %) and tumours of histologic grade 3 (56.7 %), whereas the majority of BRCA1 mutation carriers presented with stage 3–4 disease (42.9 %) and histologic grade 3 tumours (69.2 %).