Apart from the transforming growth factor-beta-induced protein (TGFBI) which is a secreted ECM component that can play an important role in tumor progression25, 26, POSTN, parathyroid hormone-like hormone (PTHLH) and secreted phosphoprotein 1 (SPP1) were also predicted to be associated with skeletal system development. The gene discussed is SPP1; the disease is neoplasm.