Since then, it has emerged that RASSF1A is one of the most frequently hypermethylated genes so far described and was reported as a prognostic indicator in renal cell carcinoma, non-small cell lung cancer, neuroblastoma, endometrial cancer and breast cancer15, 16, 17, 18, 19, 20, 21. The gene discussed is RASSF1; the disease is non-small cell lung carcinoma.