TERT and metastatic malignant neoplasm in the lymph nodes: In 222 patients with WDTC, the presence of TERT promoter mutations was associated with older age (p = 0.017), larger tumor size (p = 0.043), aggressive histologic subtypes (p < 0.001), advanced pathologic T stage (p = 0.014), extrathyroidal extension (p = 0.035), lymph node metastasis (p = 0.011), lateral lymph node metastasis (p < 0.001), distant metastasis (p < 0.001), and advanced AJCC stage (p < 0.001) (Table 2).